Modulation of the cAMP levels with a conserved actinobacteria phosphodiesterase enzyme reduces antimicrobial tolerance in mycobacteria

Michael Thomson,Kanokkan Nunta,Ashleigh Cheyne,Yi liu,Acely Garza-Garcia,Gerald Larrouy-Maumus

biorxiv（2020）

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摘要

This work represents an important milestone showing that the targeting of cAMP signalling is a promising new avenue for antimicrobial development and expands our understanding of cAMP signalling in mycobacteria.

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关键词

actinobacteria phosphodiesterase enzyme,mycobacteria,antimicrobial tolerance

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