MicroRNA-3614 regulates inflammatory response via targeting TRAF6-mediated MAPKs and NF-κB signaling in the epicardial adipose tissue with coronary artery disease

•miR-3614 is down-expressed in epicardial adipose tissue (EAT) with coronary artery disease (CAD).•Studies with cultured macrophages suggest that miR-3614 can be stimulated by toll-like receptor activators.•miR-3614 targeted TRAF6 to repress the MAPKs/NF-κB pathway in macrophages.•miR-3614 suppress inflammatory response through MAPKs/NF-κB pathway in CAD EAT, which decreases expression of the TRAF6.