MOFA+: a probabilistic framework for comprehensive integration of structured single-cell data
biorxiv(2019)
摘要
To illustrate MOFA+, we applied it to single-cell data sets of different scales and designs, demonstrating practical advantages when analyzing datasets with complex group and/or view structure. In a multi-omics analysis of mouse gastrulation this joint modelling reveals coordinated changes between gene expression and epigenetic variation associated with cell fate commitment.
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