KCND3 is a novel susceptibility locus for early repolarization

Alexander Teumer,Teresa Trenkwalder,Thorsten Kessler,Yalda Jamshidi,Marten E. van den Berg,Bernhard Kaess, Christopher P. Nelson,Rachel Bastiaenen,Marzia De Bortoli,Alessandra Rossini, Isabel Deisenhofer,Klaus Stark,Solmaz Assa,Peter S. Braund,Claudia Cabrera,Anna F. Dominiczak,Martin Gögele,Leanne M. Hall, M. Arfan Ikram,Maryam Kavousi,Karl J. Lackner,Lifelines Cohort Study,Christian Müller,Thomas Münzel,Matthias Nauck,Sandosh Padmanabhan, Norbert Pfeiffer,Tim D. Spector,Andre G. Uitterlinden,Niek Verweij,Uwe Völker,Helen R. Warren,Mobeen Zafar,Stephan B. Felix,Jan A. Kors,Harold Snieder,Patricia B. Munroe,Cristian Pattaro,Christian Fuchsberger,Georg Schmidt,Ilja M. Nolte, Heribert Schunkert, Peter Pramstaller,Philipp S. Wild,Pim van der Harst,Bruno H. Stricker,Renate B. Schnabel,Nilesh J. Samani,Christian Hengstenberg,Marcus Dörr,Elijah R. Behr,Wibke Reinhard

biorxiv（2019）

Cited 1|Views7

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Abstract

In this study we identified for the first time a genome-wide significant association of a genetic variant with ERP. Our findings of a locus in the gene not only provide insights into the genetic determinants but also into the pathophysiological mechanism of ERP, revealing a promising candidate for functional studies.

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