Targeted Therapy With Anlotinib For A Patient With An Oncogenicfgfr3-Tacc3fusion And Recurrent Glioblastoma

We describe a case of recurrent glioblastoma treated with anlotinib in this report. The patient was administered anlotinib 12 mg p.o. once every day (days 1-14, with a 21-day cycle) (anlotinib clinical study NCT04004975) and oral temozolomide chemotherapy 100 mg/m(2)(days 1-7, days 15-21, 28-day cycle; 12 cycles). After 2 months of therapy, the patient achieved a partial response that has been maintained for >17 months of follow-up. Molecular characterization confirmed the presence of aTERTpromoter mutation, wild-typeIDH1/2, anFGFR3-TACC3fusion, andFGFR3amplification in the patient. Anlotinib is a multitarget tyrosine kinase inhibitor that was originally designed to inhibit VEGFR2/3, FGFR1-4, PDGFR alpha/beta, and c-Kit. Patients withTERTpromoter mutations and high-gradeIDH-wild-type glioma have shorter overall survival than patients withIDH-wild-type glioma withoutTERTpromoter mutations. However, this patient had a favorable clinic outcome, andFGFR3-TACC3fusion may be a new marker for treatment of glioma with anlotinib. Key PointsThis case study is believed to be the first report thatFGFR3-TACC3fusion could be a novel indication to treat recurrent glioblastoma with the drug anlotinib. This case exhibited an exceptional response (maintained partial response >17 months) after 2-month combined therapy of anlotinib and oral temozolomide chemotherapy. This case also underscores the importance of molecular diagnosis for clinically complex cases. Tumor tissue-based assessment of molecular biomarkers in brain tumors has been successfully translated into clinical application.