Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a
biorxiv(2019)
Abstract
Remarkably, Rab8a activates Cdc42 in a Tuba-dependent manner, and dominant negative mutants of both GTPases reciprocally prevent the effect over polarity acquisition in the gain-of-function scenarios. Our results strongly suggest that a positive feedback loop linking Rab8a and Cdc42 activities via Tuba, is a primary event in neuronal polarization. In addition, we identified the GEF responsible for Cdc42 activation that is essential to specify axons in cultured neurons.
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Key words
neuronal polarity,axon specification,Rab-GTPases,Rho-GTPases,neuronal differentiation
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