Systematic development of peptide inhibitors targeting the CXCL12/HMGB1 interaction

Jacopo Sgrignani,Valentina Cecchinato,Enrico M.A. Fassi,Gianluca D’Agostino,Maura Garofalo,Gabriela Danelon,Giovanni Grazioso,Mariagrazia Uguccioni,Andrea Cavalli

biorxiv（2020）

引用 9|浏览7

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摘要

The identification of this peptide represents an important step towards the development of innovative pharmacological tools for the treatment of severe chronic inflammatory conditions characterized by an uncontrolled immune response.

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关键词

Peptide inhibitors,computational drug design,cell migration,inflammation,HMGB1,CXCL12,CXCL12/HMGB1 heterocomplex

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