miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin/Ambra1 signaling.

Junjun Zhou,Yan Zhao,Zhenlu Li,Meiyang Zhu,Zhecheng Wang,Yang Li,Ting Xu,Dongcheng Feng,Su Zhang,Fan Tang,Jihong Yao

Pharmacological Research（2020）

引用 36|浏览26

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摘要

•miR-103a-3p suppressed Parkin expression by targeting 3'-UTR of Parkin mRNA.•miR-103a-3p inhibition has neuroprotective effects in PD.•Parkin/Ambra1-mediated mitophagy may be involved in the mechanism of miR-103a-3p.

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关键词

AD,Ambra1,AR-PD,CQ,DA,DAPI,DOPAC,HVA,miRNAs,MPP+,MPTP,NC,ncRNAs,OD,6-OHDA,PD,Pink1,SN,UTR,TH,VDAC

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