Changes Of Vaginal Microbiota During Cervical Carcinogenesis In Women With Human Papillomavirus Infection
PLOS ONE(2020)
摘要
Objective To evaluate the changes of vaginal microbiota during cervical carcinogenesis in women with high-risk human papillomavirus infection. Materials and methods Vaginal microbiota was analyzed using next-generation sequencing in women with normal, cervical intraepithelial neoplasia (CIN), or cervical cancer. Results A marked decrease ofLactobacillus crispatuswas found in the CIN/cancer groups compared with that in the normal group. The diversity of microorganisms increased in patients with CIN or cervical cancer with HPV infection.Atopobium vaginae(OR 4.33, 95% CI 1.15-16.32),Dialister invisus(OR 4.89, 95% CI 1.20-19.94),Finegoldia magna(OR 6.00, 95% CI 1.08-33.27),Gardnerella vaginalis(OR 7.43, 95% CI 1.78-31.04),Prevotella buccalis(OR 11.00, 95% CI 2.00-60.57), andPrevotella timonensis(OR 6.00, 95% CI 1.46-24.69) were significantly associated with the risk of CIN 2/3 or cervical cancer. Conclusion Women with the CIN and cervical cancer showed a high diversity in vaginal microbiota. Depletion ofLactobacillus crispatusand increased abundance of anaerobic bacteria were detected in women with cervical disease.
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关键词
vaginal microbiota,cervical carcinogenesis,human papillomavirus infection,human papillomavirus
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