ANALYSIS OF SURVIVAL TIME AND FACTORS THAT INFLUENCE HIV/ MYCOBACTERIUM TUBERCULOSIS INFECTION

Objective: To study the survival time for patients with HIV/AIDS complicated with Mycobacterium tuberculosis infection, and factors that influence it. Methods: HIV patients in Hebei Province from January 2007 to June 2017 were included in this research. These patients either reported or were confirmed through testing, and took part in follow-up. Patients who presented with extra pulmonary tuberculosis (TB) or TB in previous follow-ups were screened. The Kaplan-Meier product limit method was used to calculate survival rate, and factors that influence the survival time of patients with double infection were analyzed using univariate and multivariate Cox proportional hazard regression models. Results: Among 728 patients with double infection, there were 350 cases (48.08 %) and 589 cases (80.90 %) of complication with TB infection within 2 months, 12 months after HIV confirmation. The 1-year survival of HIV/AIDS patients with TB infection was 80.01 %. The date on which TB infection was diagnosed during follow-up was taken as the start date of observation. By the end of November 30th, 2014, 1376 patients were followed-up in 1 year, and 167 cases of death occurred, resulting in a death density of 15 20 1100 people per year. Multivariate Cox proportional hazards regression model analysis showed that age (HR= 1.113 , 95 % CI: 1.025 - 1264), non-usage of antiviral treatment (HR = 14.018, 95 % CI: 8.517 - 21.692), and low first count of CD4 + T lymphocytes (HR=1 .452, 9.5 % CI: 1 274 - 2.945) on HIV confirmation, were high risk factors for mortality. The risk of mortality in homosexual transmission infection (HR = 0.476, 95 % CI: 0203 - 0.695) were lower than risk of mortality from non-sexually transmitted infections. Conclusion: HIV/AIDS cases complicated with TB occur within 1 year of follow-up after HIV confirmation. Age, non-sexually transmitted infections, non-usage of antiviral therapy, and low first count of CD4 + T lymphocytes are risk factors for death in patients with double infection.