Metabolic index in Mayas: association with hypercholesterolemia in patients with type 2 diabetes

It is already known that combination of insulin resistance (IR) and compensatory hyperinsulinemia increases the risk of hypertension, and atherogenic dyslipidemia. These changes increase the risk of cardiovascular disease. With that in mind, the aim of the present study was to evaluate the association between elevated metabolic index, an indirect measure of insulin resistance, and hypercholesterolemia in an indigenous Mayan population with type 2 diabetes (T2D). A total of 77 indigenous Mayan patients with a previous diagnosis of T2D were included. Biochemical variables were measured by standardized photometric methods and the metabolic index (GB x TG/HDL-C-2) was calculated. A correlation between the metabolic index and the levels of GB (r=0.333, p=0.001), 11 1 , (r=0.331, p=0.003), CT (r=0.255, j.0.026), TG (r=0.762, p=1.29 x 10(-15)), HDL-C (r=-0.735, p=4.2 x 10(-14)) was found; while there was no correlation with LDL-C concentrations (r=0.120, p=0.300). The association between the metabolic index and hypercholesterolemia (B=1.590, p=0.041, Exp(B)=4.901 and I.C=1.066-22.544) was independent of A(1c), levels, age, gender, BMI and evolution time of DT2. The study presents evidence of the association between the metabolic index and hypercholesterolemia, and proposes the potential use of the metabolic index as an indirect measure of atherogenic risk in an indigenous Mayan population with T2D.