Pharmacokinetics of echinocandins in suspected candida peritonitis: A potential risk for resistance

International Journal of Infectious Diseases(2020)

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摘要
•Peritoneal and serum concentrations of echinocandins were analysed in surgical patients with suspected candida peritonitis.•The peritoneal concentrations obtained for the three candins in the present study ranged 0.21–0.46 μg/mL for caspofungin, 0.68–0.88 μg/mL for micafungin and 0.66–1.82 μg/mL for anidulafungin, and most concentrations were <1 μg/mL.•The levels of echinocandins that were found in the peritoneum were below the concentrations of resistant mutant selection published by other authors.•These data warn about mutant selection in patients on prolonged treatment with echinocandins and suboptimal control of abdominal infection.
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关键词
Echinocandins,Pharmacokinetics,Candida,Peritonitis,Resistance
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