Prognostic Value Of Serum Aquaporin-1, Aquaporin-3 And Galectin-3 For Young Patients With Colon Cancer

Background This study aimed to investigate the long-term prognosis value of serum galectin-3, aquaporin (AQP)-1 and AQP-3 in young patients with colon cancer. Methods A total of 100 young patients with colon cancer, 100 cases of benign colon and 100 healthy people were collected. All colon cancer patients were followed up for 42 months. Results Compared with the benign lesion group and the control group, preoperative serum galectin-3, AQP-1 and AQP-3 concentrations were significantly increased in patients with colon cancer (P < 0.05). The immunohistochemistry scores of galectin-3, AQP-1 and AQP-3 in colon cancer patients were positively correlated with serum galectin-3, AQP-1 and AQP-3 concentrations (P < 0.05). Serum galectin-3, AQP-1 and AQP-3 concentrations were positively correlated with TNM staging (galectin-3:r(Pearson) = 0.502,P < 0.001; AQP-1:r(Pearson) = 0.415,P < 0.001; AQP-3:r(Pearson) = 0.454,P < 0.001) and differentiation (galectin-3:r(Pearson) = 0.377,P = 0.004; AQP-1:r(Pearson) = 0.411,P = 0.001; AQP-3:r(Pearson) = 0.483,P < 0.001). Receiver operator characteristic curve (ROC) analysis showed that the area under ROC curve (AUC) of the combination of galectin-3, AQP-1 and AQP-3 in distinguishing colon cancer was 0.907. The sensitivity in the parallel mode was 87.6%, and the specificity in the serial mode was 98.2%. Compared with the low galectin-3 group, low AQP-1 group and low AQP-3 group, the survival time of patients in the high galectin-3 group (chi(2) = 13.929,P < 0.001), high AQP-1 group (chi(2) = 10.157,P = 0.001) and high AQP-3 group (chi(2) = 4.364,P = 0.037) were significantly shortened. Conclusion Galectin-3 combined with AQP-1 and AQP-3 had important value in the identification of young patients with colon cancer and was of great value in evaluating long-term prognosis.