Glycodiversification for the Synthesis of Neomycin and Kanamycin Class Aminoglycoside Antibiotics

Aminoglycosides are an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their use and resulted in the need for novel aminoglycosides. Our group has synthesized two libraries of aminoglycosides: pyranmycin and kanamycin analogs, utilizing the glycodiversification concept. Several of them show promising activity against both susceptible and resistant strains of E coli. The structure activity relationship of these compounds further provides information for the future designs of aminoglycoside.