Synthesis of Cinnamic Acid Derivatives
PROCEEDINGS OF THE 2016 7TH INTERNATIONAL CONFERENCE ON EDUCATION, MANAGEMENT, COMPUTER AND MEDICINE (EMCM 2016)(2017)
Abstract
Quinazoline derivatives have been shown to be biologically active such as afatinib. The cinnamic acid derivative is an important part of the quinazoline derivative which exerts its activity. And Cinnamic acid derivatives were prepared by the benzaldehyde derivatives and malonic acids. In this paper, four cinnamic acid derivatives were prepared. The structure was confirmed by MS and H-1 NMR. In addition, this method not only saved the reaction time, but also improved the purity of the product. The yield of the step was about 90%.
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Key words
Cinnamic derivatives,Synthesis,Optimization
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