The Role of Galectin-3 in Stellate Cell Activation and Liver Fibrosis

Joy X. Jiang,Xiangling Chen,Hiroo Fukada,Dan K. Hsu,Fu-tong Liu, Natalie J. Toeroek

GALECTINS AND DISEASE IMPLICATIONS FOR TARGETED THERAPEUTICS（2012）

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摘要

Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin alpha v beta 3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

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