Omentin-1 promotes mitochondrial biogenesis via PGC1α-AMPK pathway in chondrocytes.

Zhigang Li,Yao Zhang,Fengde Tian,Zihua Wang,Haiyang Song,Haojie Chen,Baolin Wu

Archives of physiology and biochemistry（2023）

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摘要

Omentin-1 is a positive regulator of mitochondrial biogenesis in chondrocytes, and its action is dependent on the AMPK-PGC1α pathway. This study, therefore, implies that omentin-1 has the potential to remedy chondrocyte damage in the prevention and treatment of osteoarthritis.

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关键词

AMPKα,Omentin-1,PGC1α,chondrocytes,mitochondrial biogenesis

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