Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance

Sara M. Elgendy,Shatha K. Alyammahi,Dima W. Alhamad,Shifaa M. Abdin,Hany A. Omar

Critical Reviews in Oncology/Hematology（2020）

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Abstract

•Cancer stem cells play a crucial role in cancer drug resistance and tumor relapse.•Complete tumor eradication could be achieved by targeting cancer stem cells.•The induction of ferroptosis in CSCs is a promising target for cancer treatment.•Cancer stem cells possess unique features that render them sensitive to ferroptosis.•Ferroptosis inducing agents show great potential in eliminating cancer stem cells.

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ABC,ACSL4,ALDH,AML,BCSC,CML,CSCs,DHA,DMT1,EMT,FPN,FTH,FTL,GC,GPX,GPX4,GSH,HCC,HMLER cells,HNSCC,LOXs,MUFAs,NRF2,PUFAs,ROS,RSL3,TNBC,ZEB1

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