Case of nivolumab-induced sclerosing cholangitis: lessons from long-term follow-up
BMJ OPEN GASTROENTEROLOGY(2020)
Abstract
Nivolumab is an immune checkpoint inhibitor used to treat multiple solid-organ malignancies. While many of its immune-related adverse events are well established, nivolumab-induced sclerosing cholangitis remains poorly characterised, with no defined diagnostic criteria. Moreover, data regarding long-term outcomes are particularly lacking. We present a biopsy-proven case of nivolumab-induced sclerosing cholangitis, which uniquely captures 18 months of follow-up post-treatment. Our case highlights key features of intrahepatic subtype sclerosing cholangitis and suggests durable response to corticosteroid therapy.
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Key words
autoimmune biliary disease,cancer immunobiology,cholestatic liver diseases,drug toxicity,liver function test
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