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Restoring the Natural Tropism of AAV2 Vectors for Human Liver.

Marti Cabanes-Creus,Claus Hallwirth,Adrian Westhaus,Boaz H. Ng,Sophia Hy Liao,Erhua Zhu,Renina Gale Navarro,Grober Baltazar,Matthieu Drouyer,Suzanne Scott,Grant J. Logan,Giorgia Santilli,Antonette Bennett,Samantha L. Ginn,Geoff McCaughan,Adrian J. Thrasher,Mavis Agbandje-McKenna,Ian E. Alexander,Leszek Lisowski

Science Translational Medicine（2020）

引用 40|浏览51
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摘要
AAVs isolated from human liver are tropic for human hepatocytes in vivo, but this phenotype becomes attenuated after passage in culture.
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