Patient-derived cells from recurrent tumors that model the evolution of IDH -mutant glioma.

Lindsey E Jones,Stephanie Hilz,Matthew R Grimmer,Tali Mazor,Chloé Najac,Joydeep Mukherjee,Andrew McKinney,Tracy Chow,Russell O Pieper,Sabrina M Ronen,Susan M Chang,Joanna J Phillips,Joseph F Costello

Neuro-oncology advances（2020）

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摘要

These PDCs, scPDCs, and PDX are unique and versatile community resources that model the heterogeneous clonal origins and functions of recurrent -mutant LGGs. The integrated phylogenies advance our knowledge of the complex evolution and immense mutational load of -mutant HM glioma.

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关键词

IDH1-mutant glioma,hypermutation,intracranial xenograft,intratumoral heterogeneity and evolution,patient-derived cells

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