Low expression Macrophage Migration Inhibitory Factor (MIF) alleles and tuberculosis in HIV infected South Africans

Duncan Reid,Sheela Shenoi,Ravesh Singh,Max Wang,Vinod Patel,Rituparna Das, Keshni Hiramen,Yunus Moosa,Francois Eksteen,Anthony P. Moll,Thumbi Ndung'u,Victoria Kasprowicz,Lin Leng,Gerald H. Friedland,Richard Bucala

Cytokine: X（2019）

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摘要

•Low expression MIF alleles are prevalent in South Africa, which has the greatest burden of TB and HIV.•Low genotypic MIF expressers were more frequent among HIV cases with TB compared to those without TB.•Serum MIF correlated with lower CD4 cells regardless of TB, suggesting HIV impacts MIF expression.

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关键词

MIF,Macrophage,Tuberculosis,Immune response

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