Modulated delivery of donepezil using a combination of skin microporation and iontophoresis

•Transdermal delivery of donepezil hydrochloride for the potential treatment of Alzheimers’.•Skin microporation using polymeric microneedles and laser ablation.•Modulated delivery of donepezil via combination of skin microporation and iontophoresis.•Skin characterization: histology, confocal microscopy and scanning electron microscopy.