PB2386 BEHAVIOUR OF CIRCULATING ENDOTHELIAL CELLS IN AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH MULTIPLE MYELOMA

Background:Neoangiogenesis has a crucial role in the pathogenesis and progression of hematologic malignancies, in particular in Multiple Myeloma (MM). Circulating Endothelial Cells (CECs) are a subtype of stem cell capable to contribute to neovascularization by inducing tumor progression and metastasis and by repairing damage to bone marrow vasculature after stem cell transplantation. Different flow cytometry methods for CECs characterization have been published so far, none of them have reached consistent conclusions. However, recently, utilizing a highly optimized method based on a polychromatic flow cytometry Lyotube (BD), we proved in a national multicenter study the possibility to reach a high level standardization in CEC count and analysis.Aims:The aim of our study was to assess the kinetics of CECs in patients with MM undergoing autologous hematopoietic stem cell transplantation (ASCT …