A Study Of Universal Severe Acute Respiratory Syndrome Coronavirus 2 Rna Testing Among Residents And Staff In A Large Group Of Care Homes In South London

Agnes Marossy,Stefan Rakowicz, Angela Bhan, Sarah Noon, Amanda Rees,Manjinder Virk, Ayazali Nazafi, Evie Hay, Louise de Thomasson, Christina Windle,Mark Zuckerman

JOURNAL OF INFECTIOUS DISEASES(2021)

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摘要
Background. Care homes have experienced a high number of coronavirus disease 2019 (COVID-19)-related deaths among residents since the onset of the pandemic. However, up to May 2020, there has been a lack of information about the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents and staff in care homes and limited testing in this setting.Methods. Combined nose and throat swab testing for SARS-CoV-2 RNA was carried out in 2455 residents and staff across 37 care homes in the London Borough of Bromley across a 3-week period. Results were reported within 24 hours of sample delivery, and data were collected on the presence or absence of symptoms.Results. Overall, the point prevalence of SARS-CoV-2 infection was 6.5%, with a higher rate in residents (9.0%) than in staff (4.7%). A key finding was the high proportion of asymptomatic infection detected in staff (69%) and residents (51%), with evidence of underdetection of symptoms by care home staff.Conclusions. The high proportion of asymptomatic infection combined with underdetection of symptoms by care home staff indicates that offering a test to all residents and staff in care homes with rapid reporting of results would assist accurate identification of infected individuals, facilitating prompt infection prevention and control action.
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Coronavirus, COVID-19, SARS-CoV-2, care homes, diagnostic testing
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