An assessment of toll-like receptor 7 and 8 gene polymorphisms with susceptibility to HIV-1 infection, AIDS development and response to antiretroviral therapy

Imane Zaidane,Ahd Ouladlahsen,Rajaa Bensghir,Hajar Chihab,Fatima Zahra Jadid,Raouia El Fɩhry,Hanâ Baba,Kamal Marhoum El Filali,Mounia Oudghiri,Lahcen Wakrim,Soumaya Benjelloun,Sayeh Ezzikouri

Immunology Letters（2020）

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摘要

•TLR7 and TLR8 play an important role in activating immune response,•TLR7 polymorphisms were not associated with susceptibility to HIV-1 infection,•Met1Val of TLR8 variant modulates HIV-1 infection,•TLR7 rs179009 and TLR8 rs3764880 may modulate HIV-1 RNA viral load in male,•TLR7 and TLR8 polymorphisms not modulate the CD4 cell counts.

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HIV-1,SNPs,TLR7,TLR8,Therapy

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