AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop

Xiaojuan Han,Tianying Zhang,Xiaohua Zhang,Ruisan Zhang,Kejing Lao,Yajing Mi,Xingchun Gou

Mechanisms of Ageing and Development（2020）

Cited 8|Views11

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Abstract

•SIPS is accompanied by a dynamic fluctuation of NF-κB and STAT3 activation, and SASP production.•STAT3 signalling mediates the SASP-induced paracrine senescence.•AMPK prevents oxidative stress-induced senescence via inhibition NF-κB/STAT3 signalling -mediated positive feedback loop.

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Key words

Senescence,Oxidative stress,AMPK,SASP,NF-κB/STAT3 signalling

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