Synthetic Access to Hydrophilic Tetramate Derivatives of Cysteine.
JOURNAL OF ORGANIC CHEMISTRY(2020)
摘要
The synthesis, structural, and antibacterial evaluation of bicyclic tetramate derivatives of cysteine rendered hydrophilic with pendant heterocyclic substituents is reported; effective synthetic protocols and antibacterial activity for a small library of polar derivatives were found, and direct evidence for strong metal chelation in these systems was obtained. A computational study has developed a detailed understanding of the controlling factors of the key Dieckmann cyclization step.
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