Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
JACC: Basic to Translational Science(2020)
Abstract
•A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets.•In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow loop testing, and the valve showed trivial stenosis and trivial regurgitation.•A large animal model was used for percutaneous delivery of the valve to the fetal pulmonary annulus.•Following implantation, the valve had no stenosis or regurgitation by echocardiography, and the fetal sheep matured and was delivered at term with the tissue-engineered valve.
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Key words
congenital heart disease,tissue-engineered heart valve,transcatheter heart valve,translational medicine
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