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Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer.

Roshni D Kalachand,Ciaran O'Riain,Sinead Toomey,Aoife Carr,Kirsten M Timms,Sharon O'Toole,Stephen Madden,Mark Bates,John J O'Leary,Noreen Gleeson,Dearbhaile O'Donnell,Liam Grogan,Oscar Breathnach,Angela Farrelly,Britta Stordal,Bryan T Hennessy

Obstetrics & gynecology science（2020）

Cited 4|Views37
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Abstract
We observed a high tumor BRCA1/2 dysfunction rate in HGSC with a unique predominance of BRCA2 over BRCA1 mutations. While BRCA1/2 mutations conferred survival benefits in OC, no such association was observed with BRCA1 methylation.
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Key words
BRCA1 methylation,BRCA1 mutation,BRCA2 mutation,Ovarian cancer
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