OUTCOME OF HSC TRANSPLANTATION FOR LEUKAEMIA AFTER MYELOABLATIVE CONDITIONING USING TBI (1,000 CGY) DELIVERED IN 2 FRACTIONS, THE MANCHESTER ROYAL INFIRMARY, UK, EXPERIENCE.

BackgroundHaemopoietic stem cell transplantation for patients with haematological malignancies at the Manchester Royal Infirmary began in 1983. For logistic reasons, we have used Total Body Irradiation (TBI) at a dose of 1,000 cGy delivered in 2 fractions as part of a myeloablative conditioning. This differs from the 1,200 cGy TBI given in 6 fractions commonly used in other centres. We report here our data from 139 patients (AML, ALL and CML) who were transplanted from a fully matched sibling donor. Acute Leukaemia patients were transplanted in first CR and CML patients in chronic phase. Together with TBI, AML and CML patients received Cyclophosphamide (120 mg/kg), while ALL patients received Cyclophosphamide (120 mg/kg) or Etoposide (60mg/kg). Cyclosporin±Methotrexate was given for GVHD prophylaxis.