Epidemiology, Clinical Characteristics, And Treatment Outcomes Of Patients With COVID-19 At Siriraj Hospital – Thailand’s Largest University-Based Super-Tertiary Referral Center

Abstract Background: The epidemiology and outcomes of COVID - 19 patients in Thailand are scarce . Methods: This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020. Results: Of 1,409 patients who underwent reverse transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2, 1,029 patients (73%) had risk factors for COVID-19 acquisition of which 107 patients had laboratory-confirmed COVID-19. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive. Conclusions: The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome .