COVID-19 Orf3b protein: the putative biological function and the therapeutic target

Abstract The analysis of the COVID-19 Orf3b performed by the informational spectrum methodology suggests that this protein acts as a modulator of the interferon signaling network by binding to Karyopherin proteins. The binding site for Karyopherins on the Orf3 protein (residues 15-29) is proposed as a possible therapeutic target for COVID-19.