Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

Robert A. Hauser, Dean Sutherland,Juan A. Madrid,Maria Angeles Rol,Steven Frucht,Stuart Isaacson,Fernando Pagan, Brian N. Maddux,George Li,Winona Tse,Benjamin L. Walter,Rajeev Kumar,Daniel Kremens,Mark F. Lew,Aaron Ellenbogen,Odinachi Oguh, Alberto Vasquez,William Kinney,Matt Lowery, Maria Resnick

Clinical Parkinsonism & Related Disorders（2019）

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摘要

Orally administered ENT-01 was safe and significantly improved bowel function in PD, suggesting that the ENS is not irreversibly damaged in PD. Minimal systemic absorption suggests that improvements result from local stimulation of the ENS. A double-blind, placebo-controlled study is now ongoing.

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关键词

Squalamine,ENT-01,Parkinson's disease,Constipation,Treatment,Non-motor,Synuclein

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