Integrated study of metabolomics and gut metabolic activity from ulcerative colitis to colorectal cancer: The combined action of disordered gut microbiota and linoleic acid metabolic pathway might fuel cancer

•Developed an original nontarget metabolomics UHPLC-Q-TOF-MS/MS method.•Identified and confirmed characteristic metabolites and intestinal microbiota.•Excavated a strong correlation between typical microflora and metabolites.•Results could provide targets for the prevention and treatment of UC to CRC.