Spontaneous subcutaneous emphysema and pneumomediastinum in non-intubated patients with COVID-19

•COVID-19 patients were observed to form subcutaneous air and pneumomediastinum in the absence of mechanical ventilation.•Patients in this cohort presented mainly with respiratory symptoms including mild hypoxia, but otherwise stable vital signs.•On initial presentation, all patients demonstrated abnormalities in inflammatory markers.•On initial presentation, all patients demonstrated abnormalities in inflammatory markers.