Synthesis Of Polycyclic Indoles Via Organocatalytic Bicyclization Of Alpha-Alkynylnaphthalen-2-Ols With Nitrones
CHEMICAL COMMUNICATIONS(2020)
Abstract
A new organocatalytic bicyclization of alpha-alkynylnaphthalen-2-ols with nitrones was first reported, leading to the convergent synthesis of polycyclic indoles with substantial substitution diversity in generally good yields through scission of the N-O bond of nitronesvia[3,3]-sigmatropic rearrangement. This transformation showcases the use of a quinine catalyst in a complicated cascade system that has been shown to effectively construct polycyclic heterocyclesviaalkyne difunctionalization.
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Key words
polycyclic indoles,organocatalytic bicyclization,synthesis
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