Angiographic performance ofeverolimus-elutingstents for the treatment of coronaryin-stent restenosisin daily practice
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS(2021)
摘要
Objectives The present study aims to analyze the angiographic anti-restenotic performance of durable polymer everolimus-eluting stents (EES) for the treatment of in-stent restenosis (ISR) in daily practice. Background Randomized data is available supporting the use of drug-coated balloons and drug-eluting stents for the treatment of ISR; however, additional real-world data including angiographic follow-up is needed. Methods Patients who underwent EES-implantation for the treatment of drug-eluting stent ISR and attended for a 6-8 months angiographic surveillance were analyzed. Off-line assessment of the angiograms was conducted at a central quantitative coronary angiographic core laboratory. Results A total of 426 patients with ISR were treated with EES and had undergone angiographic follow-up. The mean age was 66.8 +/- 9.9 years and 27.5% suffered from diabetes. A total of 459 lesions were treated. The diameter stenosis decreased from 64.3 +/- 19.1% (preprocedural) to 12.0 +/- 6.4% (postprocedural). At 6-8 months angiographic follow-up, the in-segment diameter stenosis was 38.3 +/- 21.7% and the in-stent late luminal loss was 0.54 +/- 0.74 mm in the treated area analysis. The rate of recurrent binary restenosis was 25.7%. Conclusions In the setting of ISR, the angiographic anti-restenotic efficacy of stenting with EES is comparable to that observed in randomized clinical trials and less favorable than its performance in patients undergoing stenting for de novo disease.
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关键词
coronary artery disease,drug-eluting stent,percutaneous coronary intervention,quantitative coronary analysis,stent restenosis
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