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Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte macrophage colony stimulating factor–secreting breast tumor vaccine: a chemotherapy …

Leisha A Emens,Justin M Asquith,James M Leatherman,Barry J Kobrin,Silvia Petrik,Marina Laiko,Joy Levi,Maithili M Daphtary,Barbara Biedrzycki, Antonio C Wolff,Vered Stearns,Mary L Disis,Xiaobu Ye,Steven Piantadosi,John H Fetting,Nancy E Davidson, Elizabeth M Jaffee

Journal of Clinical Oncology（2009）

Cited 231|Views4
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Abstract
PurposeGranulocyte-macrophage colony-stimulating factor (GM-CSF)–secreting tumor vaccines have demonstrated bioactivity but may be limited by disease burdens and immune tolerance. We tested the hypothesis that cyclophosphamide (CY) and doxorubicin (DOX) can enhance vaccine-induced immunity in patients with breast cancer.
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