Cytogenetic Profile of Lymphoma of Follicle Mantle Lineage: Correlation

MATERIALS AND METHODSPatients and clinical parameters. Fifty-nine patients with non-Hodgkin’s lymphoma (NHL) of follicle mantle lineage were diagnosed at the Institute of Hematology, University of Ferrara (Ferrara, Italy), over a 10-year period. Histologic diagnosis was performed according to recently summarized criteria9, 28, 29 on lymph-node specimens and/or bone-biopsy sections.Of these 59 patients, 42 cases fulfilling the following criteria were included in the present study:(1) karyotype available for review.(2) Presence of the t (11; 14)(q13; q32), or the corresponding BCL1 involvement as detected by FISH technique on representative lymph-node or PB samples. FISH was shown in previous studies to be a very sensitive method for the detection of rearrangements occurring in the BCL1 locus. 2, 3 (3) Histologic picture of MCL on lymph-node specimens (28 cases with primary lymph-node involvement); or bone biopsy sections consistent with infiltration by MCL (14 patients with primary involvement of the BM and PB who had no superficial adenopathy available for