Synthesis, Characterization, and DNA Binding Properties of Dinuclear Copper(II) Complex [Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O

A dinuclear copper(II) complex [Cu2(TATP)2(L-Leu)2(ClO4)2]2·2H2O was synthesized and characterized, where, TATP=1,4,8,9-telraazatriphenylene, and L-Leu=L-leucinate. The complex was crystallized in the triclinic space group p1, with two independent molecules in a unit cell. Two Cu(II) ions in each complex [Cu2(TATP)2(L-Leu)2(ClO4)2] molecule were found to be in different coordination geometries, i.e., Cu2 or Cu4 of a distorted square-pyramidal geometry coordinated with two nitrogens of. TATP, the amino nitrogen and one carboxylate oxygen of L-Leu and one oxygen of perchlorate, and Cul or Cu3 with an octahedral geometry coordinated with the above stated similar coordinated atoms, and another carboxylate oxygen of L-Leu coordinating to Cu2 or Cu4. The complex can interact with CT-DNA by an intercalativc mode and cleave pBR322 DNA in the presence of ascorbatc.