Morphologic Analysis Of Macular Neovascularizations By Oct Angiography-Technical Limitations In The Comparison Of 3x3mm And 6x6mm Images

Background The aim of this study was to ascertain whether there are relevant differences between the vascular morphology of macular neovascularizations (MNV) in 3x3mm and 6x6mm images, produced by optical coherence tomography angiography (OCTA). Methods MNV of 49 patients were automated quantitative analysed, measuring area, flow, the fractal dimension, average vessel length, vascular density, and average vessel caliber. These parameters were compared between the 3x3mm and the 6x6mm images. Results A strong linear association was found between the 3x3mm and the 6x6mm images. While area, flow, and FD of the MNV were very similar, the 3x3mm images showed significantly lower average total vessel length, greater vascular density, and lower average vessel caliber. Conclusion In quantitative analysis of the morphologic parameters of MNV in 3x3mm and 6x6mm images, the structures are not directly equivalent in the two sizes of scan. The images must be evaluated on an individual basis.