Preparation, characterization, and pharmacokinetics of tilmicosin taste-masked formulation via hot-melt extrusion technology

Guoqing Yan,Qiuling Liang,Xuemei Wen,Jianbo Peng,Ruihan Deng,Li lv,Min Ji,Xin Deng,Liqin Wu,Xin Feng,Jiakang He

Colloids and Surfaces B: Biointerfaces（2020）

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摘要

•A novel tilmicosin formulation (TEST) was prepared utilizing hot-melt extrusion.•TEST exhibited a better taste masking effect than Pulmotil® and Tilexin.•TEST had a higher oral bioavailability than Tilexin.•This study provides a potential new formulation of tilmicosin for clinical use.

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关键词

Tilmicosin,Hot-melt extrusion technology,Taste-masked,Dissolution,E-tongue,Pharmacokinetics

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