Alterations of neuromuscular junctions in Duchenne muscular dystrophy

•Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is caused by the lack of dystrophin, a protein encoded by the DMD gene.•The neuromuscular junction (NMJ) is not a fixed, permanent structure, but instead shows plasticity in response to injury, exercise, and aging.•NMJs in the mdx mouse model of DMD show aberrant changes in both pre- and post-synaptic NMJ structure, which could influence neuromuscular transmission.•The hypothesis that the NMJ contributes to functional deficits in DMD represents a paradigm shift from more prevalent myo-centric perspectives.