Long-term uveal and capsular biocompatibility of a new fluid-filled, modular accommodating intraocular lens
JOURNAL OF CATARACT AND REFRACTIVE SURGERY(2021)
Abstract
Purpose: To evaluate long-term uveal and capsular biocompatibility of a new fluid-filled modular accommodating intraocular lens (IOL) consisting of base and fluid lenses. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA. Design: Experimental study. Methods: Bilateral phacoemulsification was performed on 8 rabbits; 1 eye received the test IOL (Juvene) and the other a hydrophobic acrylic control IOL (SA60A1). Slitlamp examinations were performed at postoperative weeks 1 and 4, and at months 2, 3, and 6. The rabbits were killed humanely at 6 months. After gross examination from the Miyake-Apple view, IOLs were removed for implant cytology. All globes were then processed for histopathologic examination. Results: Uveal biocompatibility was similar between test and control IOLs up to 6 months postoperatively. Anterior capsule opacificatbn appeared absent in the test group, and posterior capsule opacification (PCO) was significantly less in comparison with the control group throughout the study. At 6 months, central PCO was scored as 0.12 +/- 0.23 with test IOLs and as 4.0 +/- 0 with control IOLs (P < .0001, 2-tailed t test: paired 2-sample for means). Histopathologic examination confirmed the relative lack of capsular opacification in test eyes in comparison to controls and the absence of toxicity in any eye. Conclusions: Six weeks in the rabbit model corresponds to approximately 2 years in the human eye for PCO. In this model, the Juvene IOL maintained an open and expanded capsular bag, preventing overall capsular bag opacification while retaining excellent uveal and capsular biocompatibility. Copyright (C) 2020 Published by Wolters Kluwer on behalf of ASCRS and ESCRS
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Key words
capsular biocompatibility,intraocular lens,long-term,fluid-filled
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