Clinical And Germline Risk Factors For The Occurrence Of Multiple Treatment Toxicities During Childhood Acute Lymphoblastic Leukemia (All) Therapy

Marion K Mateos,Toby N Trahair,Chelsea Mayoh,Pasquale M Barbaro,Carly George,Rosemary Sutton,Tamas Revesz,Draga Barbaric,Jodie Giles,Frank Alvaro,Francoise Marie Mechinaud,Daniel R Catchpoole,Rishi Sury Kotecha,Michael CJ Quinn,Georgia Chenevix-Trench,Stuart MacGregor,Luciano Dalla-Pozza,Glenn M Marshall

BLOOD（2017）

Cited 0|Views28

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Abstract

Treatment-related toxicities can be severe, life-threatening events that impact on delivery of ALL therapy and impair quality of life. The occurrence of multiple (≥ 2) toxicities in any one individual is of particular clinical concern, due to cumulative short and long-term impacts on health and functioning. Few studies have examined the co-occurrence of and risk factors for multiple non-infectious, non hematological toxicities in children with ALL.

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Key words

childhood acute lymphoblastic leukemia,acute lymphoblastic leukemia,multiple treatment toxicities,germline risk factors,acute lymphoblastic

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