Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes

Michael C. Cox,Scott C. Brakenridge,Julie A. Stortz,Russell B. Hawkins, Dijoa B. Darden,Gabriela L. Ghita,Alicia M. Mohr,Lyle L. Moldawer,Philip A. Efron,Frederick A. Moore

The American Journal of Surgery（2020）

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摘要

•Over 1/3rd of progressed to chronic critical illness (CCI, ≥14 days in ICU with persistent organ dysfunction).•CCI patients had prolonged elevation of markers of proinflammation, immunosuppression, and metabolic derangement.•CCI patients had 1-year mortality (42%) double that of 30-day mortality (19%), with dismal 1-year performance status.

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关键词

Abdominal sepsis,Chronic critical illness,Long-term outcomes,Persistent inflammation,Immunosuppression,And catabolism syndrome

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