PDLIM2 protects articular chondrocytes from lipopolysaccharide-induced apoptosis, degeneration and inflammatory injury through down-regulation of nuclear factor (NF)-κB signaling

Qinyue Guo,Jing Xu,Qindong Shi,Shufang Wu

International Immunopharmacology（2020）

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摘要

•PDLIM2 was decreased in chondrocytes in response to LPS exposure.•PDLIM2 overexpression inhibited LPS-induced chondrocyte injury.•PDLIM2 blocked LPS-induced activation of NF-κB.•PDLIM2 protected from LPS-induced injury by inhibiting NF-κB.

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关键词

Chondrocyte,Inflammation,NF-κB,Osteoarthritis,PDLIM2

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