592PQuality of life in patients with liver metastases from colorectal cancer treated with first line selective internal radiotherapy (SIRT): Results from the FOXFIRE …

Background: Quality of life (QoL) in patients with colorectal cancer and liver metastases treated with selective internal radiotherapy (SIRT) using Yttrium-90 resin microspheres combined with FOLFOX (standard chemotherapy) has not been compared to FOLFOX alone. We report QoL results from a prospectively pooled analysis of 3 multicentre randomized trials: FOXFIRE, FOXFIRE-Global and SIRFLOX.Methods: Patients were randomized to FOLFOX or FOLFOX+ SIRT in 14 countries. Second-line therapy was permitted upon disease progression. EORTC QLQ-C30 and EuroQoL EQ-5D (3 level) questionnaires were given to all patients at baseline, 2-3, 6 and 12 months from starting treatment and yearly thereafter, and at disease progression. We compared QoL scores between arms at each timepoint, calculating mean differences adjusted for baseline scores, using a 5% significance level. No missing data …