First demonstration of real-time in-situ dosimetry of X-ray microbeams using a large format CMOS sensor

Microbeam radiotherapy is a novel type of radiotherapy in which narrow beams of radiation (typically less than 500μm) are spatially fractionated, delivering a non-uniform distribution to the target tumour volume. Due to the very high dose gradients and very small beams involved, new dosimetric techniques are required for translation into clinical practise. Current real-time beam monitoring is typically performed using 1 dimensional silicon strip detectors or wire chambers, with 2D beam information measured offline using radiochromic film (requiring a minimum of 24 h to self-develop).